摘要
目的观察法半夏罗汉果川贝枇杷膏对大鼠的长期毒性作用。方法以健康SD大白鼠为受试对象,法半夏罗汉果川贝枇杷膏分别按63.9、19.2及9.6g/kg体重灌胃给药,连续给药30d。给药前后及停药15d后,分别测定受试大鼠的体重、血液学及血生化学、重要器官脏器系数并做病理学检查等指标。结果口服法半夏罗汉果川贝枇杷膏30d,大鼠一般状况未见明显差异,对大鼠的体重增长、外周血象、血液生化学指标、脏器系数及各组织器官的病理形态均未见有显著影响,与对照组基本一致。结论法半夏罗汉果川贝枇杷膏给药30d对大鼠无明显毒性反应,未见延迟性毒性,表明该品口服应用是安全的。
Objective To investigate the long-term toxicity of Fabanxialuohanguochuanbeipipa paste in rats.Methods The healthy SD rats were treated respectively with 30-day oral administration of high,middle and low-doses of the Fabanxialuohanguochuanbeipipa paste.The body weight of rats,hematological and biochemical parameters and organ coefficient were separately determined and the pathological examination of the rats was also performed before and after the administration and at the restoration stage (15 days after the administration).Results General state of the rats was not obviously changed,as compared with that of control subjects,including growth of weight,routine blood test,blood biochemistry,tissue and organs'state,except for a few parameters.Conclusion The Fabanxialuohanguochuanbeipipa paste shows very low toxicity in long-term toxicity test by oral administration in rats,which suggests that the drug is quite safe for long-term oral administration.
出处
《河北医药》
CAS
2005年第5期387-388,共2页
Hebei Medical Journal