小剂量米索前列醇用于妊高征引产的疗效观察

Curative Effect of Misoprostol in Minimium Dose on Inducted Labor in Pregnancy Induced Hypertension

目的:探讨小剂量米索前列醇(米索)用于妊高征引产的可行性及对母儿的安全性,同时观察使用硫酸镁对产程和产后出血的影响。方法:将110例妊高征有引产指征,单胎头位无宫缩的初产妇随机分为两组,研究组58例,对照组52例,分别用小剂量米索前列醇和催产素引产,两组产妇应用硫酸镁的情况无差异。结果:引产总有效率研究组为96.6%,对照组为73.1%,差异有显著性(P<0.01)。剖宫产率研究组为18.9%,对照组为46.2%,差异有明显性(P<0.01)。宫颈评分不高于5分的初产妇,研究组中引产成功率高于对照组(P<0.05)。产时应用硫酸镁可引起潜伏期时间延长,而总产程时间无明显增加(P>0.05)。产后出血量无显著差异(P>0.05)。结论:小剂量米索前列醇重复阴道置药用于妊高征引产,疗效显著且安全、方便,有推广价值。

Objective: To investigate the feasibility and safety of misoprostol on induced labor in pregnancy induced hypertension (PIH) and observe the effect of magnesium sulfate (MgSO_4) on labor and postpartum hemorrhage. Methods:110 primiparae of PIH with indication of induced labor were randomly divided into two groups:research group (n=58) with misoprostol in minimum dose and control group (n=52) with oxgtocin.There was no difference in usage of MgSO_4 between two groups.Results:The effective rate of induced labor and uterine-incision delivery in research group and control group was 96.6% and 18.9%,73.1% and 46.2%,respectively,the difference was significant (P<0. 01).In primiparae with cervixscores less than 5,the successful rate of induced labor in research group was higher than that in control group (P<0. 05).MgSO_4 prolonged the latent period,but not contributed to total stage of labor and amount of postpartum hemorrhage (P>0. 05). Conclusion:Minimium dose of misoprostol in vagina is effective,safe,simple in induced labor of PIH.The methods should be recommended.