盐酸氨溴索针剂两种不同给药方式预防新生儿呼吸窘迫综合征效果的研究(附200例分析)

To evaluate the effects of ambroxol by two ways on prevent of premature neonatals with respiratory distress syndrome

目的探讨盐酸氨溴索针剂两种不同的给药方式预防新生儿呼吸窘迫综合征效果。方法A组早产儿,随机分为沐舒坦组和对照组;B组孕妇随机分为沐舒坦组和激素组,观察两组新生儿呼吸窘迫综合征(RDS)及其并发症的发生率。结果A组:(1)沐舒坦组RDS发生率为25.0%,对照组为66.7%,两组有显著差异(P<0.01);(2)沐舒坦组RDS的严重程度较对照组轻,有显著差异(P<0.05);(3)沐舒坦组支气管肺发育不良、脑室内出血及获得性肺炎的发生低于对照组(P<0.01)。B组:(1)沐舒坦组早产儿RDS发生率为15.9%,激素组为34.1%,两组有显著性差异(P<0.05);(2)沐舒坦组RDS的严重程度较激素组轻,有显著差异;(3)沐舒坦组早产儿获得性肺炎明显低于激素组(P<0.05)。结论对产前母亲未用过激素的早产儿生后立即静脉给沐舒坦以及给孕妇产前静脉给沐舒坦均可以降低早产儿RDS的发病率及其并发症的发生率。两种给药方式无显著差异。

Objective To evaluate the effects of ambroxol on premature neonatals to prevent respiratory distress syndrome(RDS).Methods A group premature neonates,randomly divided into two groups,ambroxol and control.B group pregnant women were fandomly divided into two groups:receving ambroxol and corticosteroids group.Observe the occurrence rate and severity of RDS.Results A group(1)Occurrence rate of RDS was 25% in ambroxol group and was 66.7% in control group,there was a significant difference(P<0.01).(2)The degree of RDS in the ambroxol group was significantly lighter than in the control group(P<0.05).(3)The incidence of premature associated complications(bronchopulonary dysplasia(BPD),intraventricular haemorrhage,and post-natal acquired pneumonia were obviously reduced in ambroxol group.B group (1)The occurrence rate of prematre infant RDS in ambroxol group is 15.9% while that in dexamethasone group is 34.1%.Two groups have a remarkable difference(P<0.05).(2)The severity of RDS are lesser than that in dexamethasone group.Rate of acquired pneumonia of premature infant in ambroxol group is remarkable lower than that in dexamethasone group(P<0.05).Conclusion It is available that ambroxol is used in premature infants immediately after birth of antenatal ambroxox usage can also reduce the incidences of RDS and its complications.The two ways have no difference(P>0.05)。