1Francesco D. Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol, 1993, 55: 451～467.
2Chen J, Piper DR, Michael C. Voltage sensing and activation gating of HCN Pacemaker Channels. Trends Cadiovasc Med,2002, 12: 42～45.
3Accili EA, Proenza C, Baruscotti M, et al. From funny current to HCN channels, 20 years of excitation news. Physiol Sci,2002, 17: 32～37.
4Santoro B, Grant SG, Bartsch D, et al. Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci, 1997, 94: 14815～14820.
5Gauss R, Scifert R, Kaupub B. Molecular identification of a hyperpolarization-activated channel in sea urchin sperm. Nature,1998, 393: 583～591.
6Ludwig A, Zong XG, Hofmann F, et al. Structure and function of cardiac pacemaker channels. Cellular Physiology and Biochemistry, 1999, 9: 179～186.
7Biel M, Schneider A, Wahl C. Cardiac HCN channels: structure, function, and modulation. Trends in Cardiovascular Medicine, 2002, 12 (5): 206～213.
8Chen J, Mitcheson JS, Lin M, et al. Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel. J Biol Chem, 2000, 275: 36, 465～36, 471.
9Blondel O, Vandecasteele G, Gastineau M, et al. Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium. FEBS Lett, 1997, 412: 465～474.
10Kaumann AJ, Sanders L. 5-hydroxytryptamine causes rate-dependent arrhythmias through 5-HT receptors in human atrium:facilitation by chronic β-adrenoceptor blockade. Naunyn Schmiedebergs Arch Pharmacol, 1994, 349: 331～337.
3Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents:from molecules to physiological function [ J ]. Annu Rev Physiol,2003 ,65 :453-480.
4Biel M, Schneider A, Wahl C. Cardiac HCN channels: structure, function, and modulation [ J ]. Trends Cardiovasc Med, 2002, 12 (5) :206-212.
5Tu H, Deng L, Sun Q, et al. Hyperpolarization-activated, cyclic nucleotide-gated cation channels : Roles in the differential electrophysiological properties of rat primary afferent neurons [ J ]. J Neurosci Res,200d,76 (5) :713-722.
6Femandez-Velaseo M ,Goren N,Benito G,et al. Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts [ J ]. J Physio1,2003,553 (Pt) :395-405.
7Hiramatsu M, Furukawa T, Sawanobori T,et al. Ion channel remod- eling in cardiac hypertrophy is prevented by blood pressure reduction without affecting heart weight increase in rats with abdominal aortic banding [ J ]. J Cardiovasc Pharmacol, 2002, 39 ( 6 ) : 866-874.
8Borlak J, Thum T. Hallmarks of ion channel gene expression in end-stage heart failure [ J ]. FASEB J,2003,17 ( 12 ) : 1592-1608.
9Nolan MF, Malleret G, Lee KH,et al. The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebcllar Parkinjc cells [ J ]. Cell,2003,115 ( 5 ) :551 - 564.
10Nolan MF, Malleret G,Dudman JT,et al. A behavioral role for dendritic integration: HCNI channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons [J]. Cell,2004,119(5) :719-732.
