肺炎支原体感染红霉素治疗时不良反应预防的探讨

Study on Prevention of Side Reaction of Erythromycin in Treating Mycoplasma Infection

【目的】研究不同添加疗法预防肺炎支原体(MP)感染红霉素治疗时不良反应的效果,寻找最佳的添加方法。【方法】对350例因MP感染需要使用红霉素静脉滴注治疗的患儿,随机分为7组,每组50例,其中1组作为对照组,不使用任何添加治疗,另外6组为观察组,分别采用6542、思密达、西咪替丁、维生素K1、微量碳酸氢钠、维生素B6添加治疗,观察其预防红霉素不良反应的效果。【结果】6542组仅10例有轻度胃肠道反应,1例重度胃肠道反应;思密达组轻度胃肠道反应者11例,重度胃肠道反应者3例;西咪替丁组轻度胃肠道反应者17例,重度胃肠道反应者6例;维生素K1组轻度胃肠道反应者15例,重度胃肠道反应者8例;微量碳酸氢钠组轻度胃肠道反应者19例,重度胃肠道反应者5例;维生素B6组轻度胃肠道反应者18例,重度胃肠道反应者9例;对照组轻度胃肠道反应者19例,重度胃肠道反应者10例。6542组与思密达组比较无显著性差异(P>0.05),而与其他各组比较差异均非常显著(P<0.01)。【结论】添加6542或思密达预防MP感染红霉素治疗时的不良反应的效果最佳。

[Objective]To study the effect of different adding therapies for preventing the side reaction of eythromycin in treating mycoplasma infection and to seek the optimum agents.[Methods]Three hundred and fifty children suffered from mycoplasma pneumoniae and treated by erythromycin intravenous drip were randomly divided into 7 groups, 50 for each.One group without any addition was used as control,the other 6 groups for experiment. 654-2, smecta, cimetidine, vitamine K1 , sodium bicarbonate, vitamine B6 were added to observe their prevention effect of side reaction of erythromycin to gastrointestinal tract.[Results]Ten cases had slight gastrointestinal side reaction and 1 cases had severe one in 654-2 group, 11 cases slight and 3 cases severe in smecta group, 17 cases slight and 6 cases severe in cimetidine group, 15 cases slight and 8 cases severe in vitamin K1 group, 19 cases slight and 5 cases severe in sodium bicarbonate group, 18 cases slight and 9 cases severe in vitamin B6 group, 19 cases slight and 10 cases severe in control group. There was no marked difference between 654-2 and Smecta groups( P >0.05 ) , while the differences were significant compared with other groups( P <0.01).[Conclusion]654-2 or smecta is optimal selection in prevention of the side reaction of erythromycin in treating mycoplasma infection.