艾司洛尔预防小儿全麻气管插管及拔管时心血管反应的临床观察

Clinic Study on Esmolol to Prevent the Cardiovascular Effects During Intubation and Extubation in the Children Undergoing Total Intravenous Anesthesia and Endotrachea Intubation

【目的】评价盐酸艾司洛尔预防小儿全麻气管插管与拔管时心血管反应的临床效果。【方法】60例择期手术病人随机分为两组:A组静脉注射艾司洛尔0.2mg·kg-1;B组静脉注射生理盐水2ml作为对照。观察麻醉前、插管前1min、插管时和插管后1、5、10min以及拔管时和拔管后1、5、10min两组患儿HR、MAp变化。【结果】两组患儿基础MAP、插管前1min及插管后10min和拔管后10minMAP差异无显著性,其余各个时间点A组患儿MAP均低于B组差异有显著性(P<0.05)。基础HR、插管前1min及插管后10min和拔管后10minHR无显著性差异,其余各个时间点A组患儿HR均低于B组,差异有显著性(P<0.05)。【结论】艾司洛尔可减轻小儿全麻气管内插管和拔管所致的心血管反应。

[Objective]To evaluate the efficacy of esmolol to prevent the cardiovascular effects of the children undergoing total intravenous anesthesia and trachea intubation.[Methods]Sixty infants were divided into two groups.Group A was injected esmolol 0.2mg/kg and group B was injected saline 2ml intravenously respectively before anesthesia induction. HR and MAP were recorded immediatly before administratim, before tubation ,and 1, 5 ,10 minutes after intubation, and 1, 5 ,10 minutes after extubation.[Results]There were significant difference in the HR and MAP between Group A and Group B( P <0.05).[Conclusion]Esmolol can significantly relieve the cardiovascular effects of the children undergoing intravenous anesthesia and endotracheal intubation.