两种治疗消化性溃疡方案的成本效益分析

Cost-effectiveness analysis of two types of treatment for peptic ulcer

目的：探讨一组低毒、高效、价廉而又适应于农村治疗幽门螺杆菌（Hp）相关性消化性溃疡（PU）的药物方案。方法：经胃镜诊断和Hp快速尿素酶实验阳性的活动性PU随机分为观察组79例用庆大霉素8万单位＋雷尼替丁150mg；对照组86例用奥美拉唑20mg＋羟氨苄青霉素1000mg＋甲硝唑400mg,均为每日两次餐后口服，服药2周停药1周后复查。结果：观察组与对照组总有效率分别为88．6％和90．7％；Hp消除率为87．7％和90.7％，两组比较差异无显著性（p＞0．25），而观察组与对照组2周治疗的药品费用分别为13．00元和659．00元，差异显著。结论：观察组治疗Hp相关性PU疗效与对照组相当，而费用是对照组的1／50。符合低毒、高效、价廉的用药原则。

In order to explore a set of highly-effective and cheap medicine for treatment of helicobacter pylori(Hp) peptic ulcer (PU) in rural area,165 active PU patients with positive clo test and gastrosceopic examination were randomly divided into two groups, group 1 (n=79)received gentamycin 80 000μtogether with ranitidine 150mg bid for 14 dsys, group Ⅱ (n = 86) received omeprazoleastra 20mg, together with amoxicillin 1000mg,metronidazole 400mg bid for 14 days.The author reexamined 165 patients 7 days later after the treatment was finished.Research result showed that effective rate for group Ⅰ and group Ⅱ was 88.6% and 90.7% respectively (p> 0.25),HP eliminating rate was 87.7% and 90.7% respectively (p>0. 25),the treatment expenditure was 13.00 yuan and 659 .00 yuan respectively (p> 0.001). Author suggested gentamicin together with ranitidine was highly effective and cheaper in treating Hp peptic ulcer.