蒺藜皂苷对大鼠实验性急性心肌缺血的保护作用

Protective effects of Gross Saponin of Tribulus Terrestris on acute myocardial ischemia in rats

目的:观察注射用蒺藜皂苷(GSTT)对垂体后叶素和异丙肾上腺素致大鼠急性心肌缺血模型的影响。方法:分别采用舌下静脉注射垂体后叶素和腹腔注射异丙肾上腺素制备二种大鼠急性心肌缺血模型,观察GSTT对垂体后叶素致急性心肌缺血模型大鼠心电图异常改变和心率减慢的影响及异丙肾上腺素致心肌缺血模型大鼠血清肌酸磷酸激酶(CPK)和乳酸脱氢酶(L DH)的影响。结果:与模型组比较,GSTT可减轻垂体后叶素引起的心率减慢程度(P<0 .0 1,P<0 .0 5 )和S- T段抬高程度(P<0 .0 5 ) ,GSTT高剂量组可明显降低异丙肾上腺素致急性心肌缺血大鼠血清CPK和L DH活性(P<0 .0 1)。结论:GSTT对大鼠实验性急性心肌缺血有保护作用。

Objective To investigate the effects of Gross Saponin of Tribulus Terrestris (GSTT) on acute myocardial ischemia in rats. Methods The acute myocardial ischemia models were established by isoproternol subcutaneous injection and pituitary sublingual venous injection respectively. The effects of GSTT on the electrocardiogram T-wave of isoproternol inducing acute myocardial ischemia and the serum contents of LDH and CK of pituitary inducing acute myocardial ischemia were observed. Results GSTT with doses of 10.4,20.8,and 31.2 mg·kg -1 could significantly improve the decreased heart rates induced by isoproternol (P<0.01, P<0.05);GSTT with dose of 31.2 mg·kg -1 could remarkably increase the activities of serum LDH and CPK in acute myocardial ischemia rats (P<0.01).Conclusion GSTT can protect myocardium in rats with acute myocardial ischemia.