麝鼠香与麝香抗炎及镇痛作用的比较研究

Comparison of anti-inflammation and analgesia between muskrat and moschus

目的:研究麝鼠香与麝香的抗炎及镇痛作用。方法:利用扭体法,对比观察麝鼠香与麝香的镇痛作用;应用二甲苯致炎模型及醋酸所致小鼠腹腔毛细血管通透性增加模型对比观察麝鼠香与麝香的抗炎作用。结果:麝鼠香与麝香均能明显减少冰醋酸所致的小鼠扭体次数(P<0 .0 5或P<0 .0 1) ,显著抑制二甲苯引起的小鼠耳肿胀(P<0 .0 5或P<0 .0 1) ,同剂量给药,麝香组的作用明显强于麝鼠香组;麝鼠香与麝香对醋酸所致的小鼠腹腔毛细血管通透性增加性炎症反应有明显的抑制作用(P<0 .0 5或P<0 .0 1) ,相同剂量给药,二者的作用差异无显著性(P>0 .0 5 )。结论:麝鼠香有类麝香样抗炎及镇痛作用。

Objective To study the effects of muskrat and moschus of anti-inflammation and annalgesia. Methods The effects of muskrat and moschus of anti-inflammation were observed by using torsive-body method. The effects of muskrat and moschus of analgesia were observed by mice inflammation models caused by dimethylbenzene and mice models with reinforce permeability of abdominal cavity capillary caused by acetic acid.Results Both muskrat and moschus could significantly reduce the times of torsive-body in mice caused by glacial acetic acid (P<0.05 or P<0.01). And they obviously inhibited ear swelling of mice caused by dimethylbenzene (P<0.05 or P<0.01). The effects of moschus were more obvious than muskrat when they were given with the same dosage. Muskrat and moschus had obvious inhibitory effects on mice inflammation of reinforce permeability of abdominal cavity capillary caused by acetic acid (P<0.05 or P<0.01).They had no difference of effects when they were given with the same dosage(P>0.05). Conclusion Muskrat and moschus have the same effects of anti-inflammation and analgesia.