氧化苦参碱对大鼠血压的影响

Effects of oxymatrine on blood pressure in rats

目的:观察氧化苦参碱(OMT)对大鼠血压的影响。方法:将4 8只Wistar大鼠随机分为6组(n=8) ,即生理盐水组,OMT30、6 0和90 m g·kg- 1 组以及普萘洛尔加OMT6 0 mg·kg- 1 组和多沙唑嗪加OMT6 0 m g·kg- 1组。常规颈动脉插管,股静脉给药,应用BL- 4 2 0生物机能实验系统记录大鼠血压及心率。结果:静脉给予OMT30、6 0和90 mg·kg- 1具有剂量依赖性地降低血压的作用,OMT能增强多沙唑嗪的降压作用,但与普萘洛尔无协同降压作用。结论:OMT的降压作用呈现剂量依赖性,且与多沙唑嗪具有协同的降压效应。

Objective To investigate the effects of oxymatrine (OMT) on blood pressure in rats. Methods Fourty-eight Wistar rats were randomly divided into 6 groups (n=8):normal saline group,OMT groups with different doses(30,60,and 90 mg·kg -1 ),propranolol+OMT 60 mg·kg -1 group and doxazosin+OMT 60 mg·kg -1 group. Cannula was cannulated commonly into carotid artery and connected with BL-420 BioLab System to record the blood pressure and heart rate(HR) in rats. Results Mean arterial pressure(MAP) were significantly lower than control in dose-dependent manner after intraventous adminstration of OMT(30,60,and 90 mg·kg -1 ). Conclusion OMT can decrease the MAP in dose-dependent manner. OMT and doxazosin have synergetic effects on MAP.