检测宫颈阴道分泌物中胰岛素样生长因子结合蛋白-1预测早产的价值

The value of insulin-like growth factor binding protein-1of cervicovaginal secretion in the prediction of premature labor

目的:探讨检测胰岛素样生长因子结合蛋白-1(IGFBP-1)能否用于预测早产。方法:应用快速免疫法检测218例孕妇宫颈阴道分泌物中高磷酸化GFBP-1的含量。结果:先兆早产组IGFBP-1的阳性率是62.0%,正常妊娠组IGFBP-1的阳性率是9.1%,两组结果比较,差异有显著性。先兆早产IGFBP-1的阳性组发生早产率是83.6%。结论:检测IGFBP-1可以作为预测早产的客观指标。

Objective:To study whether the phosphorylated insoforms of insulin-like growth factor binding protein-1(IGFBP-1)of cerˉvicovaginal secretion for predicting premature labor.Methods:The phosphorylated isoforms of IGFBP-1of cervicovaginal secretion in218pregˉnant women was measured by a immunochromatography.Results:The positive rate of IGFBP-1was62.0%in the threatened premature labor group and9.1%in the normal group,with significant differnce between two groups(P<0.05).The premature labor rate in the threatened preˉmature labor group with positive reaction of IGFBP-1was83.6%.Conclusion:Detecting the phosphorylated isoforms of IGFBP-1can be used as a objective index for predicting premature labor.