米氮平与帕罗西汀治疗抑郁症的对照研究

Comparative study of mirtazapine and paroxetine in the treatment of depression

目的:比较米氮平与帕罗西汀治疗抑郁症的临床疗效及完全性。方法:65例符合CCMD-3诊断的抑郁症患者,分为米氮平组(33例)和帕罗西汀组(32例),观察6周,疗效评定用汉密顿抑郁量表(HAMD),不良反应评价用副反应量表(TESS)。结果:米氮平组有效率为78.79%,帕罗西汀组为75%。两组比较差异无显著性(P>0.05),但米氮平起效快,不良反应轻。结论:米氮平是一种完全、有效的抗抑郁药。

Objective:To compare the efficacy and safety of mirtazapine and paroxetine in the treatment of depression.Methods:65patients who met CCMD-3criterion for drepression were randomly divided into mirtazapine group(n=33)and paroxetine group(n=32).The patients in two groups were treated with mirtazapine or paroxetine for6weeks respectively.The efficacy was assessed by Hamilton depression rating scale(HAMD)and the safety was assessed by treatment emergent sympton scale(TESS).Results:The effective rate of the mirtazapine group was78.79%,the paroxetine group was75%,without remarkable difference between two groups(P<0.05)。The response was rapid and side effects were slight in mirtazapine group,compared with those in paroxetine group.Conclusion:Mirtazapine is an effective and safe antidepressant.