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干扰素联合利巴韦林治疗慢性丙型肝炎的临床观察

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摘要 目的:观察普通干扰素联合利巴韦林治疗慢性丙型肝炎的疗效。方法:治疗组32例慢性丙型肝炎患者采用普通干扰素联合利巴韦林治疗,对照组30例慢性丙型肝炎患者采用普通干扰素治疗,于治疗前、治疗24周结束,及随访24周分别检测肝功ALT、HCVRNA。结果:治疗组24周后肝功复常率为76.6%、HCVRNA阴转率为80.0%,治疗结束后随访24周ALT复常率为66.7%、HCVRNA阴转率为63.3%。与对照组疗效比较差异有显著性。结论:普通干扰素联合利巴韦林治疗慢性丙型肝炎效果显著,价格适中,值得进一步推广和应用。
出处 《现代医药卫生》 2005年第11期1351-1352,共2页 Journal of Modern Medicine & Health
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  • 1林文,张俊平,胡振林,钱定华.苦参碱对细菌脂多糖诱导大鼠枯否细胞释放肿瘤坏死因子及白细胞介素-6的影响[J].药学学报,1997,32(2):93-96. 被引量:68
  • 2Carman WF,Jacyna MR,Hadziyannis S,et al.Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection[J].Lancet.1989,11:588-591
  • 3Hadziyannis S, Bramou T, Makris A, et al. Interferon alfa- 2b treatment of HBeAg negative / serum HBV DNA positive chronic active hepatitis type B[J]. J Hepatol, 1990, 11(Suppll):133-136.
  • 4Hultgren C,Milich DR,Weiland O,et al.The antivirial compound ribavirin modulates the T heplper(Th)Th1/Th2 subset balance in hepatitis B and C virus-specific immune responses[J].J Gen Virol,1998,79:2381-2391
  • 5Lai CL, Chien RN, Leung NW, et al. A one-year trial of lamivudine for chronic hepatitis B.Asia Hepatitis Lamivudine Study Group[J].N Engl J Med,1998,3398
  • 6Schiff ER. Lamivudine for hepatitis B in clinical practice [J]. J Med Virol, 2000, 61 (3): 386.
  • 7Dong Y, Xi H, Yu Y, et al. Effects of oxymatrine on the serum levels of T helper cell 1 and 2 cytokines and the expression of the S gene in hepatitis B virus S gene transgenie mice: a study on the antihepatitis B virus mechanism of oxymatrine [J]. J Gastroenterol Hepatol, 2002, 17 (12): 1299.
  • 8de Man RA, Marcellin P, Habal F, et al. A randomized, placebocontrolled study to evaluate the efficacy of 12-month famciclovir treatment in patients with chronic hepatitis B e antigen-positive hepatitis B [J]. Hepatology, 2000, 32 (2): 413.
  • 9Trepo C, Jezek P, Atkinson G, et al. Famciclovir in chronic hepatitis B: results of a dose-finding study [J].J Hepatology,2000, 32 (6): 1011.
  • 10Hoofnagle JH, Di Bisceglie AM. The treatment of chronic viral hepatitis [J]. N Engl J Med, 1997, 336 (5): 347.

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