一氧化氮治疗对急性高原病患者血浆四参数的影响及意义

The Effect of NO Treatment on Plasma ET, NPY, ANP and CGRP in AHAD Patients and Its Significance

目的了解一氧化氮(NO)对急性高原病(AHAD)患者血浆内皮素(ET)、神经肽Y(NPY)、心钠素(ANP)及降钙素基因相关肽(CGRP)的影响及意义。方法将47例AHAD患者随机分为常规药物治疗组(23例)和NO治疗组(24例)。并对两组患者治疗前后的血清NO及血浆ET、NPY、ANP、CGRP及临床症状评分的变化情况进行对照比较(NO以其代谢终产物NO3-和NO2-代替)。结果两组患者治疗后的血浆ET、NPY和ANP及临床症状评分均显著降低,NO和CGRP则显著升高(其中常规药物治疗组P<0.05,NO治疗组P<0.01),两组治疗后结果相比较亦具有显著性差异(P<0.05)。且治疗前血清NO与血浆ET呈显著负相关(r=-0.63,P<0.001),与血浆CGRP呈显著的正相关(r=0.38,P<0.01)。结论一氧化氮能使AHAD患者血浆ET、NPY、ANP显著降低,NO和CGRP显著升高,对AHAD患者的康复有着积极的作用。

Objective To explore the significance and effect of NO treatment on plasma ET, NPY, ANP and CGRP in acute high altitude diseases(AHAD) patients. Methods 47 AHAD patients were randomly divided into two groups, one group receiving routine medicine treatment (n=23), and the other group receiveing NO treatment (n=24). The level changes of serum NO, plasma ET, NPY, ANP and CGRP and clinical symptom score were compared before and after treatment in the two groups. Results The levels of plasma ET, NPY, ANP and CGRP, and clinical symptom score remarkably decreased after treatment in two groups, while serum NO and CGRP levels remarkably increased (P<0.05, P<0.01). There was a significant difference in efficacy between the two groups(P<0.05). Serum NO level was negative correlation with plasma ET level(r=-0.63,P<0.001), and positive correlation with plasma CGRP level (r=0.38,P<0.01) before treatment. Conclusion NO could remarkably decrease the levels of plasma ET, NPY and ANP in AHAD patients. The increase of NO and CGRP level had active effect for AHAD patient recovery.