高敏C反应蛋白和白细胞介素-6与2型糖尿病微血管病变的关系

The Relationship between High-sensitivity C-reactive Protein,Interlukin-6 and Microangiopathy in Patients with Type ≥Diabetes Mellitus

目的:探讨高敏C反应蛋白和白细胞介素-6与2型糖尿病微血管病变的关系。方法:分别用胶乳增强免疫比浊法和ELISA法测定112例2型糖尿病患者(其中微血管病变72例,无微血管病变者40例)及42例正常对照组的血清hs-CRP和IL-6水平。结果:112例2型DM患者的hs-CRP和IL-6浓度比42例正常对照显著增加[(13.78±8.32)mg/Lvs(1.09±0.39)mg/L,P<0.01],[(17.02±7.72)vs(6.42±2.67)ng/L,P<0.01]。糖尿病组中微血管病变者的血清hs-CRP[(14.11±7.45)mg/L]和IL-6[(19.51±8.01)ng/L]水平显著高于无微血管病变者有血清hs-CRP[(2.34±1.45)]和IL-6[(12.01±5.65)]水平(P<0.01)。hs-CRP与IL-6呈高度正相关(r=0.693,P<0.01)。结论:hs-CRP和IL-6浓度在2型DM患者中显著增加,且在并发微血管病变者的2型DM患者增加更显著,血清hs-CRP和IL-6浓度增高可能是糖尿病微血管病变者的重要危险因素。

Objective:To investigate the relationslip betwwen high-sensitivity C-reactive protein,interlukin-6 with microangiopathy in patiens with type 2 diabetes mellitus.Methods:Serum hs-CRP concentration was measured using particle enhanced immunoturbidimetric method and IL-6 was measured by ELISA in 112 type 2 diabetes mellitus(72 with microangiopathy,40 without microangiopathy)and in 42 controls.Results:Serum hs-CRP and IL-6 consentration in 112 patients with type 2 DM was significanttly increased than that in 42 controls[(13.78±8.32)mg/L vs(1.09±0.39)mg/L,P<0.01],[(17.02±7.723)vs(6.42±2.67)ng/l,P<0.01].Among type 2 DM patients,hs-CRP [(14.11±7.45)mg/L]and IL-6[(19.51±8.01)ng/L]in type 2 diabetes mellitus with microangiopathy increase significantly in comparison hs-CRP[(2.34±1.45)mg/L]and IL-6[(12.01±5.65)ng/L]in type 2 diabetes mellitus without microangiopathy.hs-CRP concentration was significantly correlated with level of IL-6(r=0.693,P<0.01).Conclusion:Serum hs-CRP and IL-6 concentration was significantly increased in type 2 DM patients,especially in type 2 DM patients with microangiopathy.Serum hs-CRP and IL-6 may play an important role in the pathogenesis of type 2 diabetes mellitus with microangiopathy.