高强度聚焦超声治疗中晚期原发性肝癌的疗效观察

The Effect of High Intensity Focused Ultrasound on Patients with Advanced Primary Liver Cancer

目的:观察高强度聚焦超声对中晚期原发性肝癌的治疗效果。方法:追踪随访自2002年5月至2003年12月底高强度聚焦超声治疗的81例原发性肝癌患者的预后情况。结果:术后疼痛症状缓解率为60.9%,纳差症状缓解率为43.9%;术后3月生存率69.1%,6月生存率33.3%,9月生存率16.7%,1年生存率10.8%;术后生存期较其自然病程延长;术后常见死亡原因为肝功能衰竭、上消化道大出血、恶病质、癌块破裂大出血,其中以肝功能衰竭、上消化道大出血为主;患者术后生存期与肝癌分期、肝硬化基础病变及治疗后AFP下降程度密切相关。结论:高强度聚焦超声治疗中晚期肝癌可一定程度上减轻患者症状、改善患者生存质量、延长患者生存时间,是一种很有发展前景的无创外科治疗肝癌的方法。

Objective:To assess the effect of HIFU(High Intensity Focused Ultrasound)treatment on patient with advanced Primary Liver Cancer(PLC).Methods:The prognosis of 81 patients treated with HIFU from May 2002 to December 2003 was followed up.Results:The survival rate of the patients treated with HIFU at 3 months was 69.1%,at 6 months was 33.3%,at 9 months was 16.7%,at 1 year was 10.8%.There was significance between natural survival period of the patients with PLC and that of treated with HIFU.The chronic cancer pain was reliveed in 60.9% patients after HIFU.Conclusion:HIFU can prolong the survival period of the patients with advanced PLC and improve the quality of their lives.