胰岛素样生长因子结合蛋白2在消化道恶性肿瘤诊断中的意义

Clinical significance of serum insulin-like growth factor bindin g protein-2 in patients with digestive tract malignant tumor

目的评价胰岛素样生长因子结合蛋白2(IGF-BP2)血清水平在消化道恶性肿瘤的临床意义。方法用酶联免疫吸附试验法测定137例消化道恶性肿瘤患者、17例胃肠良性息肉患者和40例健康对照者血清IGF-BP2的水平。结果原发消化道恶性肿瘤组血清IGF-BP2水平为(768.17±166.44)μg/L,显著性高于胃肠良性息肉组(414.17±39.25)μg/L、健康对照组(388.65±34.43)μg/L及21例原发消化道恶性肿瘤手术治疗患者(410.56±57.93)μg/L(均P<0.001)。结论IGFBP2为一高度敏感的恶性肿瘤标记物,临床上检测血清IGF-BP2水平,对于筛查和辅助诊断消化道恶性肿瘤及判断预后都具有重要意义。

Objective To evaluate the clinical significance of se rum insulin-like growth factor-binding protein-2(IGF-BP2) in patients with d igestive tract malignant tumor. Methods Enzyme-linked immunosorbent assay was used to detect the level of serum IGF-BP2 in 137 patients with digestive tract malignant tumors,17 patients with digestive tract polyps and 40 healthy individuals. Results The level of serum IGF-BP2 in the patients with digestive tract malignant tumor was ( 768.17± 166.44) μg/L. The result was sign ificantly higher than that of digestive tract polyps ( 414.17± 39.25) μg/L(P< 0.001) and healthy individuals ( 388.65± 34.43) μg/L( P< 0.001). Conclusion The high level of IGF-BP2 has high sensitivity and spe cificity in malignant tumor, and it can be a good indicator in the screening, di agnosis and estimating the prognosis of digestive tract malignant tumors.