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赖氨酸羟化酶的研究进展 被引量：2

Advances in the Study of Lysyl Hydroxylase
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摘要 赖氨酸羟化酶(lysyl hydroxylase,LH)是催化胶原蛋白和另外15种以上蛋白质中赖氨酸羟化的酶类,它在一些生理和病理过程中扮演着重要的角色。LH有多种同工酶,其活性需依赖一些辅基的存在,同时也受到一些物质的抑制。研究发现一些组织纤维化性疾病和遗传性疾病与LH有很大的关系。近年来,随着对该酶研究的深入,有望找到这些疾病治疗的新靶点。 Lysyl hydroxylase (LH) catalyzes the hydroxylation of lysine in collagens and more than 15 other proteins and it plays an important role in the physiological and pathological processes in the human beings. LH has a variety of isoenzymes, the functions of which depend on some cosubstrates and can be inhibited by some substances. Previous researches have shown that it is related with some fibrotic and inherited diseases and futher study of the enzyme may help us find new targets for the treatment of the diseases.
作者 谭彬 罗忠金 张吉翔
机构地区 江西省分子医学重点实验室 江西医学院第二附属医院消化科
出处 《医学分子生物学杂志》 CAS CSCD 2005年第3期220-223,共4页 Journal of Medical Molecular Biology
基金 国家自然科学基金(No.30160032)~~
关键词 赖氨酸羟化酶 纤维化 Ⅵ型Ehlers-Demlos综合征 Brock综合征 lysyl hydroxylase fibrosis Ehlers-Demlos syndrome Ⅵ type Bruck syndrome
分类号 R596 [医药卫生—内科学] Q554.9 [生物学—生物化学]
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参考文献22

  • 1Kivirikko KI, Pihlajaniemi T.Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases.Adv Enzymol Relat Areas Mol Biol,1998,72: 325-98.
  • 2Rautavuoma K,Takaluoma K,Passoja K,et al. Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3.The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity.J Biol Chem,2002,277(25): 23 084-91.
  • 3Mercer DK,Nicol PF,Kimbembe C,et al. Identification,expression,and tissue distribution of the three rat lysyl hydroxylase isoforms.Biochem Biophys Res Commun,2003,307(4):803-9.
  • 4van der Slot AJ,Zuurmond AM,Bardoel AF,et al. Identification of PLOD2 as telopeptide lysyl hydroxylase,an important enzyme in fibrosis.J Biol Chem,2003,278(42):40 967-72.
  • 5Wang C,Risteli M,Heikkinen J,et al.Identification of amino acids important for the catalytic activity of the collagen glucosyltransferase associated with the multifunctional lysyl hydroxylase 3 (LH3).J Biol Chem,2002,277(21):18 568-73.
  • 6Rautavuoma K,Takaluoma K,Sormunen R,et al. Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice.Proc Natl Acad Sci USA,2004,101(39):14 120-5.
  • 7Kellokumpu S,Sormunen R,Heikkinen J,et al.Lysyl hydroxylase,a collagen processing enzyme,exemplifies a novel class of luminally-oriented peripheral membrane proteins in the endoplasmic reticulum. J Biol Chem,1994,269(48):30 524-9.
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医学分子生物学杂志
2005年 第3期

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