头孢地尼体外抗菌活性和作为头孢哌酮序贯治疗药物的研究

Antibacterial activity of cefdinir in vitro and its clinical function in sequential therapy for lower respiratory tract infection

目的:检测头孢地尼体外抗菌活性,同时观察在下呼吸道感染中,作为第3代头孢菌素序贯治疗药物的作用。方法:用琼脂培养基纸片扩散法检测头孢地尼及其他11种抗生素对4种菌属:葡萄球菌、肺炎克雷伯菌、铜绿假单胞菌、不动杆菌共117株细菌体外药物敏感性,同时观察该药对下呼吸道感染患者作为头孢哌酮序贯治疗药物的效果。结果:头孢地尼对葡萄球菌的敏感率与头孢曲松、头孢哌酮、头孢噻肟、头孢他定、头孢比肟、头孢唑林相似(P>0.05),较氧氟沙星、诺氟沙星、左氧氟沙星、环丙沙星强(P<0.05)。头孢地尼对肺炎克雷伯菌的敏感率与头孢哌酮、头孢曲松、头孢呋辛、头孢噻肟、头孢唑林、头孢他啶相似(P>0.05),较头孢吡肟弱(P<0.05)。不动杆菌与头孢吡肟、头孢他啶、头孢曲松、头孢呋辛、诺氟沙星、氧氟沙星、左氧氟沙星、环丙沙星相似(P>0.05),对铜绿假单胞菌敏感率低(敏感率13.33%)。头孢地尼作为头孢哌酮序贯治疗药物,与对照组比较,痊愈率和显效率无明显差别(c2=0.200,P>0.05)。结论:头孢地尼对葡萄球菌、肺炎克雷伯菌、不动杆菌较敏感,可作为第3代头孢菌素序贯治疗药物。

Objective:To evaluate the antibacterial activity of cefdinir in vitro and observe its effect in sequential therapy for lower respiratory tract infection. Methods: Antibacterial activity of cefdinir, as a third generation of cephalosporin, and other 11 antibacterial agents against 4 types of flora (staphylococci, K.pneumoniae, pseudomonas aeruginosa, acinetobacter, tatally 117 bacteria) in lower respiratory tract infection were determined with paper spreading method. Results: The susceptibility rate of cefdinir against staphylococci(85.7%)was similar to ceftriaxone, against K.pneumoniae (65.63%)was similar to cefoperazone, against acinetobacter was similar to cefepime, ceftazidime, cefuroxime, against pseudomonas aeruginosa was (13.3%)very lower. Conclusion: Cefdinir is sensitive to staphylococci,aeruginosa and K.pneumoniae, it can be used as a third generation of cephalosporin in sequential therapy for sensitive bacterial infections.