斯普林联合HDLF方案治疗中晚期消化道恶性肿瘤的临床观察

The clinical observation of sipulin plus HDLF to middle and late malignant tumors of digestive tract

目的观察斯普林对中晚期消化道恶性肿瘤辅助疗效。方法将80例中晚期消化道肿瘤病人随机分为两组:斯普林组:HDLF加斯普林组;对照组:单用HDLF组。治疗前后对患者外周血白细胞、红细胞、血色素、血小板、肝肾功能、食欲、消化道反应、疼痛、体重、Karnofsky评分、疗效进行评价。结果斯普林组白细胞减少程度及疗效均好于对照组,临床症状及生活质量,斯普林组显著改善,两组比较有显著差异(P<0.05,P<0.01),免疫指标CD3、CD4、CD4/CD8、NK活性显著提高,两组比较有显著差异(P<0.05)。结论HDLF方案加斯普林可以增加疗效、减轻骨髓毒性及消化道反应、提高机体免疫力、提高病人生存质量和化疗耐受性。

Objective To observe possible auxiliary effect of sipulin for the middle and late malignant tumors of digestive tract. Methods Eighty patients were randomly divided into two groups, one was sipulin group(HDLF plus sipulin) , another was comparison group(only with HDLF). The leukocyte, red blood cell, haemoglobin and platelet, toxicity of digestive tract, pain response, body weight, state of Karnofsky and effective rate of those patients were evaluated respecively before and after therapy. Results The clinical effect and reduce of leukocyte were better in sipulin group than in comparison group,the quality of life and clinical symptom of the patients in sipulin were improved more obviously than those in comparison group(P<0. 005,P<0. 01), the results of CD3, CD4, CD4/CD8and NK were higher in sipulin group than in comparison group,the difference was statisically significant (P<0. 05). Conclusion SIPULIN combination HDLF can improve the effect, reduce the toxicities of digestive tract and blood, enhance the immunity and quality of life,increase tolerance of patients for chemotherapy.