胶质瘤MRI增强与微血管密度和肿瘤增殖活性的相关性

MRI enhancement in gliomas and its correlation with microvascular density and tumor cell proliferation

目的探讨胶质瘤MRI增强程度与微血管密度、肿瘤增殖活性的关系。方法回顾分析62例胶质瘤的MRI增强程度和用免疫组化法分析MVD和PCNA标记指数,研究MRI增强程度与MVD和PCNA标记指数的关系。结果62例中45例有增强,并与MVD和PCNA标记指数明显相关(P<0.01)。MVD和PCNA标记指数也明显相关(P<0.01)。结论术前胶质瘤MRI增强与其微血管密度和细胞增殖活性明显相关,提示MRI增强能较好的反映胶质瘤的血管新生化和肿瘤增殖活性。

Objective To study the correlation between MRI enhancement and microvessle density,tumor cell proliferation in glio-ma. Methods Sixty-two cases of cerebral gliomas were studied retrospectively. Patients were examined before surgery with contrast-enhanced MR imaging. Microvessel densities and the cell proliferation rates of tumor specimens were measured by immuno-histochemically using factor VIII and PCNA antibodies. Contrast enhancement of the tumors was evaluated by two radiologists. Results Contrast enhancement was observed in 45 tumors and was correlated with histologic cell proliferation (P<0. 01) and microvessel density (P<0. 01). There was also a correlation between tumor vascular density and the cell proliferation rate (r = 0. 65,P<0. 01). Conclusion The enhancement on preoperative contrast-enhanced MR imaging correlates with vascularity and proliferation activity of gliomas, which suggests that contrast-enhanced MR imaging could be useful in estimating intra-tumoral microvessel density and tumor cell proliferation.