紫杉醇每周疗法联合奥沙利铂、氟尿嘧啶治疗32例晚期胃癌

Efficacy of paclitaxel combined with oxaliplatin and fluorouracil for weekly treatment of 32 cases of advanced gastric cancer

目的观察紫杉醇每周疗法联合奥沙利铂,氟尿嘧啶治疗晚期胃癌的近期疗效及毒副反应。方法紫杉醇60mg/m2第1、8、15d,静脉输注3h;奥沙利铂85mg/m2,第2、9d,静脉输注2h;第3d氟尿嘧啶1000mg腹腔灌注(每周1次,共6-8次),以上方案应用于32例晚期胃癌患者,静脉化疗3周为1个周期,2周期后评定疗效。结果全组32例病例:CR5例,PRl4例,NC11例,PD2例,总有效率为59.3%,获益率93.7%,其中肝转移患者治疗有效率达69.2%,淋巴结转移治疗有效率达63.1%。毒副反应主要为骨髓抑制、脱发、神经毒性及恶心、呕吐等,患者均可耐受。结论紫杉醇每周疗法联合奥沙利铂,氟尿嘧啶治疗晚期胃癌是一个疗效高,毒副反应可耐受的好方案。

Objective To evaluate the efficacy and safety of combination of paclitaxel .oxaliplatin and fluorouracil(5-Fu) in patients with advanced gastric cancer (AGC). Methods Thirty two patients with AGC receieved paclitaxel 60mg/m2 (3-hour intravenous infusion,d 1,8,15) followed by oxaliplatin 85mg/m2 (2-hour intravenous infusion,d2,9) and 5-Fu l000mg (intraperitone-al infusion d3 once weekly ,6-8 times in all ) every 3 weeks, and were evaluated after 2 cycles. Results All of the 32 patients completed the whole cycles. The overall response rate was 59. 3 %, PR 93. 7%,. And the response rate was 69. 5 %, 63. 1 % in lymph node metastasis. The main adverse effects were BMD, alopacie, neurotixicity and nausea/vomiting. The adverse effects were tolerable. Conclusion This paclitaxel + oxaliplatin + 5Fu reginmen show good efficacy and tolerable toxicity in ACG patients.