EHF患者抗原及微核检测临床诊断价值的探讨

Study on clinical diagnostic value of detection of antigen and micronucleus in patients with epidemic hemorrhagic fever

本文应用RFC—SPA法对临床诊断的42例流行性出血热（EHF）患者外周血抗原及微核进行了检测。抗原阳性率为93％，其对照组抗原检测为阳性，两组比较差异显著（P〈0．01），微核率为5．07‰，其对照组做核率为0．57‰（P〈0．01）。试验组微核率高与抗原阳性率高相符。试验结果表明RFC－SPA抗原检测是简易、早期、快速诊断流行性出血热的可靠方法，可以在基层单位推广。淋巴细胞微核率可作为流行性出血热的早期诊断及病情预测的一项新的辅助指标，抗原及微核检测具有临床应用价值。

This artical reports that antlgen and lymphocyte forcronucleus in peripheral blood of 42 patients suffered from epidemic hemorrhagic fever (EHF) were detected. The results showed that 39 patients were positive by RFC-SPA,the positive rate was 93%, their control groups were negative(P<0.01 ). The antigen Positve rate in the febrile phase and shock phase in the course of the disease was the highest (100%),but did not appear to related to patients condition.The micronucleus rate of the experiment groups was 5. 07%, but that of the control group was 0. 57% (P<0. 01 ). the thecronucleus rate in febrile phase and severe EHF was higher. It was found that the high micronucleus rate coincided with the high antigen positive rate. These data suggested that detection of EHF antigen by RFC-SPA is simple,easy,and rapid for the early diagnosis of the disease,this method could be extensively recommended to the grass roots level. The wieronucleus rate of lymphocyte of patients with EHF has early diagnostic and progres sive value.