螺旋霉素对牙周炎活动破坏发生率的影响

A influence of spiramycin on incidence of periodontal disease activity

本文对7例牙周炎患者的170颗牙、970个部位于治疗结束后作为纵向观察时的基线。以后每隔2个月定点复查1次，共观察了6～12个月、以2次检查之间新出现≥2mm的附着丧失作为活动期的诊断标准，比较了口服螺旋霉素和服药结合牙周刮治治疗后牙周炎活动破坏的发生率。结果表明：牙周炎活动破坏的估计年发生率为2．8％，单纯口服螺旋霉素和服药结合牙周刮治的两组牙齿，其活动破坏的发生率无显著差异（P＞0．1）。说明螺旋霉素治疗牙周炎的远期效果仍较好。提示螺旋霉素可以作为牙周炎患者有效的辅助用药。

This research observed a longitudinal effect of spiramycin therapy on periodontitis. The incidence of active tissue destruction that was associated with new attachment loss (AL) was ex andned. 6- 12 months f0llowing clinjcal observation of 970 sites in 7 treated periodontitis patients has been taken. AL of≥2mm between two consecutive visits has been required to designate a site as periodontal disease activity (PDA). The results showed that the estimated incidence of PDA in treated periodontitis sites was 2. 8% per year. There was not significant difference between the in cidence of PDA of combiningy spiramycin therapy group with curettage and those of spiramycin therapy group. The findings suggest spiramycin may be used an adjunctive meth0d for treating pe riodontitis.