碱性成纤维细胞生长因子在前列腺癌中的表达

Expression of basic fibroblast growth factor(bFGF)in prostatic carcinoma tissues.

目的探讨碱性成纤维细胞生长因子(bFGF)在前列腺癌中表达的临床意义。方法应用半定量RT-PCR技术和免疫组织化学方法,检测22例前列腺癌组织中bFGF的表达,并与正常的前列腺组织进行比较。结果前列腺癌组织中的bFGF表达高于正常的前列腺组织(P<0.05);bFGF表达升高的程度与前列腺癌病理分级和临床分期均无明显关系。结论前列腺癌组织中bFGF的表达高于正常前列腺组织,提示bF-GF与前列腺癌的发生发展密切相关。

ObjectiveTo investigate the clinical significance of expression of basic fibroblast growth factor(bFGF)in prostatic carcinoma (Pca)tissues. Methods The expression levels of bFGF mRNA in 22 sample of prostatic carcinoma tissues and normal prostate tissues were detected by semi-quantitive RT-PCR, while the expression level of bFGF protein were detected by immunohistochemical staining and quantitative analysis. Results The expression levels of both bFGF mRNA and protein in prostatic carcinoma tissues were higher than those in normal prostate tissues (P<0.05). There was no significant correlation between the increased expression of bFGF and the pathologic grading as well as clinical stages of Pca. Conclusion The expression of bFGF in Pca tissues was higher than those in nomal prostate tissues. bFGF is closely involved in the genesis and development of Pca.