原发性结外非霍奇金淋巴瘤127例临床特征及误诊分析

Clinical features and misdiagnosis analysis of primary extranodal non-hodgkin lymphoma .

目的分析淋巴结外非霍奇金淋巴瘤(NHL)的临床表现特点及误诊原因。方法回顾性分析127例原发结外非霍奇金淋巴瘤的发病情况、原发部位分布情况、首发症状及误诊情况等。结果原发于结外的非霍奇金淋巴瘤127例,占同期非霍奇金淋巴瘤53.81%(127/236);原发部位前5位依次为:胃肠道21.26%(27/127),鼻腔18.9%(24/127),Waldeyer环14.96%(19/127),脾脏12.6%(16/127),皮肤6.3%(8/127);结外奇非霍金淋巴瘤误诊率为69.29%(88/127);结外非霍奇金淋巴瘤首发症状因原发部位不同而临床表现各异,无特异性。结论结外NHL发生率较高,其临床表现缺乏特异性,早期易误诊。

Objective To observe the characteristic of clinical manifestation and analyze the cause of misdiagnosis of primary extranodal non-Hodgkin lymphoma(NHL). Methods All 127 cases of NHL, diagnosed with patholo-gical examination in our hospital from 1997 to 2002, were analyzed to investigate the incidence, extranodal site, clinical characteristics and misdiagnosis of primary extranodal non-Hodgkin lymphoma. Results Among 236 patients of NHL 127 cases (53.81%) were diagnosed as primary extranodal NHL; the developing sequence of common extranodal sites were: gastrointestinal lymphoma 21.26%(27/127),nasal lymphoma 8.9%(24/127), Waldeye's ring lymphoma 14.96%(19/127), splenic lymphoma 12.6%(16/127) and cutaneous lymphoma6.3%(8/127). Misdiagnosis rate of primary extranodal NHL was 69.29%(88/127). Symptoms and signs of primary extranodal NHL were quite different based on different extrnodal sites and of no specific characteristics. Conclusion The incidence of primary extranodal NHL is relative high. The primary extranodal NHL can be misdiagnosed as other common diseases because its signs are of no specific characteristics.