FOLFOX7方案治疗晚期胃肠道肿瘤的疗效观察

Efficacy of FOLFOX7 regimen in the treatment of advanced gastrointestinal carcinoma.

目的观察FOLFOX7方案在治疗晚期胃肠道肿瘤中的作用。方法L-OHP130mg/m2静脉滴入,2h,d1;CF500mg/m2静脉滴入,2h,d1;5-Fu2.4～3.0/m2.Civ.46～48小时,21d重复最少2个疗程后评价疗效。结果24例患者中,完全缓解0例(CR),部分缓解12例(PR)50%,稳定9例(NC)37.5%、进展4例(PD)16.67%。毒副反映较轻。特殊毒性是外周神经感觉异常,停药消失。骨髓抑制不明显,只有1例为Ⅳ度抑制。较轻微胃肠道反应。结论FOLFOX7方案应用于治疗晚期胃肠道肿瘤有一定疗效,可一定程度提高患者生活质量,且毒副反应轻,较易耐受。

Objective To evaluate the efficacy of FOLFOX7 in the treatment of advanced gastrointestinal carcinoma.Methods Oxaliphatin was administered as a 2-hour infusion at a does of 130mg/m^2 on day 1 ;Leucovorin 500mg/m^2 on day 1; Fluorouracil 2.4~3.0/m^2,continued 46~48hours.The treatment was repeated every 21days with at least two cycles .Results Twenty-four patients were evaluated for treatment outcome, no one obtained CR,12PR,9NC,4PD and the overall response rate was 50%.A dose-related and reversible peripheral sensory neuropathy was the dose-limiting toxicity. The adverse reaction was tolerable.Conclusion The FOLFOX7 is a effective regimen for patients with advanced gastrointestinal carcinorna ,with a manageable toxicity.