高IgE综合征外周血T淋巴细胞亚群和皮肤迟发反应的研究

Analysis of T-lymphocyte subgroups of the peripheral blood and skin DTH in patients with hyper-IgE syndrome

目的:探讨高IgE综合征病人的细胞免疫功能。方法:分别检测5例高IgE综合征病人和15例健康人的外周血T淋巴细胞亚群和对破伤风类毒素、纯结核菌素的皮肤迟发反应情况。结果:高IgE综合征组外周血CD4+细胞计数比健康对照组显著低(P<0.01),而CD8+细胞计数则比健康对照组高(P<0.01);高IgE综合征病人皮肤迟发反应试验的硬结直径显著小于健康对照组(P<0.01)。结论:高IgE综合征存在T淋巴细胞免疫缺陷,且T淋巴细胞在本病的发病过程中起重要作用。

Objective: To study the function of cellular immunity of patients with hyper-IgE syndrome (HIE). Methods: T-lymphocyte subgroups of the peripheral blood and cutaneous delayed-type hypersensitivity (DTH) to two recall antigens: tetanus toxoid (TT) and purified protein derivative(PPD) were measured in 5 patients with HIE and 15 healthy controls, respectively. Results: The CD4 + cells counted in the HIE group were significantly lower than those in the control group (P<0.01). In contrast, CD8 + cells were significantly higher than those in the controls. The induration sizes induced by DTH to two recall antigens were smaller in HIE patients than those in controls (P<0.01). Conclusion: There is immunological dysfunction of T lymphocyte in the patients with HIE and T cells play an important role in the pathogenesis of HIE.