掌跖脓疱病患者血清瘦素高水平表达的研究

Study on the increased serum leptin level in palmoplantar pustulosis

目的:研究掌跖脓疱病的血清瘦素水平,探讨掌跖脓疱病与血清瘦素水平的相关性。方法:21例掌跖脓疱病患者与正常对照28例,采用放射免疫技术检测其血清瘦素,并进行统计学分析。结果:(1)掌跖脓疱病患者血清瘦素水平(9.56±5.30)ng/mL较正常对照(5.62±2.93)ng/mL显著增高(P=0.002);(2)血清瘦素水平可见显著的性别差异(P=0.001),与女性正常对照(6.60±2.69)ng/mL比较,女性掌跖脓疱病血清瘦素水平(9.85±5.25)ng/mL显著增高(P=0.017);(3)血清瘦素水平与掌跖脓疱病的发病年龄、病程无相关性。结论:掌跖脓疱病与血清瘦素水平相关,瘦素可能在掌跖脓疱病的发生及发展过程中起作用。

Objective: To evaluate serum leptin concentrations in patients with palmoplantar pustulosis, and to investigate whether palmoplantar pustulosis correlates with leptin level. Methods: The serum leptin concentration (ng/mL) was measured by radioimmunoassay (RIA) in 21 patients with palmoplantar pustulosis (19 females, 2 males) aged 41.71±14.11 on average and 28 body mass index (BMI)-, age- and sex-matched healthy volunteers. And the findings were analyzed statistically. Results: The serum leptin concentration in patients with palmoplantar pustulosis (9.56±5.30) ng/mL was significantly (P=0.002) higher compared to that in healthy controls (5.62±2.93) ng/mL. There was significantly different serum leptin concentration between the female and the male subjects (P=0.001). The serum leptin concentration in female patients(9.85± 5.25) ng/mL were significantly (P=0.017) higher than the female controls(6.60±2.69) ng/mL. There was no correlation between serum leptin level and the onset age and duration of the disease. Conclusion: The serum leptin concentration is correlated with patients with palmoplantar pustulosis. Leptin may play a role in the pathogenesis of palmoplantar pustulosis.