携超广谱β-内酰胺酶肺炎克雷伯氏菌的流行状况及耐药性观察

Observation on epidemiological situations and durg resistance of Klebsiella pneumoniae strains producing Extended--Spectuum β--lactamases

目的了解安徽某地区携超广谱β-内酚胺酶(ESBLs)肺炎克雷伯氏菌的流行状况及耐药特征。方法从临床送检标本中分离出的肺炎克雷氏菌经双纸片法筛选、Etest验证,获取携ESBLs菌进行药敏试验。结果共分离到肺炎克雷伯氏菌127株,其中携ESBLs菌52株,检出率为40.94％。携ESBLs肺炎克雷伯氏菌对14种抗生素均存在不同程度的耐药,仅亚胺培南和头抱三嗪的耐药率为0。结论该地区携ESBLS肺炎克雷伯氏菌的流行情况十分严重,亚胺培南和头孢三嗪是治疗本菌感染的首选药物。

Objective To probe into epidemiological situations and drug resistance of Klebsiella pneu- moniae strains producing Extended-Spectrum β-lactamases (ESBL) in certain area in Anhui Province. Meth- ods Klebsiella pneumoniae strains were isolated form clinical specimens and thus ESBL-producing strains were selected strains for the with double disk test and E-test, Drug sensitive test was performed at last. Results A total of 127 strains of K.pneumoniae were acquired, and the detectable rate of the ESBL-producing strains was 40.94%(52/127). The ESBL-produeing strains was resistant to 14 kinds of antibiotics, but the drug resistant rates of the ESBL-producing to imipenem and cefatrizzine were zero. Conclusion The epidemiological situa- tions of ESBL-pmducing Klebsiella pneumoniae strains was severe, and imipenem and cefatrizzin were the flint choice for treatment of patients infected by this ESBL-producing strains.