血浆成分分离治疗类风湿性关节炎21例

Treatment of rheumatoid arthritis by plas-ma fractionation in 21 cases

１９９２年１０月以来，对２１例类风湿性关节炎共进行了７１人次血浆成分分离治疗（ＰＦ），平均１－２周内进行３．６人次，并在治疗前后进行总体评估。结果示：疗程完成后，全部病例的体力活动和实验室指标均有不同程度改善，３例活动受限者治疗后均能自由行走。平均每次分离血浆５７３１±１２９ｍｌ，其中ＩＣ，ＩｇＧ，ＩｇＧ，ＩｇＡ，均有统计学意义的减少。血沉从８０．２１±３４．００ｍｍ／ｈ降到５１．４０±３１．２８ｍｍ／ｈ，８例类风湿因于阳性的患者中，５例阴转，作者认为ＰＦ正在成为一种实用的技术，并可能是治疗类风湿关节炎最好的方法之一。

71 sessions of plasma fractionation(PF) were performed in 21 cases of rheuma-toid artritis (RA) since October , 1992 in ourunit. The patients were treated with averageof 3. 6 PF sessions within 1￣ 2 weeks andwe evaluated the patients before and afterthe course. The improvements of physicalconditions and lab tests had been observedin various degree after the therapies in allpatients. Three patients in limited ambula-tion studied regained independent walking.The mean volume of separated plasma was5731 ± 1291ml per session. A statistical sig-nificant reduces of IC, IgG, IgA and IgMwere found not only after the course ,but al-so the one session of therapy in most cir-cumstances. The rnean of ESRs was quicklydecreased from 80. 21± 34. 00 mm H2O be-fore therapies to 51. 40± 31. 28mm H2O lat-er only in interval of 19. 25± 5. 25 days afterinitiation of the therapies. In addition, fivepositive RF out of eight ones turned to neg-ative by the end of the course. It is suggest-ed that PF technique is becoming applicableand may be one of the best therapies for RAtreatments.