头孢唑肟在血透期间体内药动学特点及给药方法

The pkarmacokinetics of Ceftizome inbemodialysis patients

本文测定了４例血透患者透析期间动静脉端益保世林（ＣＺＸ）血药浓度的变化及透析液中的排出量，经微机自动拟合处理，得出透析期间ＣＺＸ的药动学参数。结果提示，ＣＺＸ可被透析器有效清除。综合药动学参数和透析后血药浓度变化．建议一般感染在血透前给予ＣＺＸ１．０ｇ，血透后补充０．５ｇ；严重感染在血透前给予ＣＺＸ２．０ｇ。血透后补充１．０ｇ，以期达到维持较高峰浓度和校长时间，并最大程度地减少副作用的目的。

he concentration of the Ceftizome(CZX) in blood and dialysate duringhemodialysis (HD) have been investigated infour renal failure patients. The pharma-cokinetics parameters of the CZX were tak-en after computer automatic fit. The resultshown that CZX have been effectivelycleared during HD. To maintain the rnaxinaleffect and rninimal side effect , we suggest,CZX is given I g before HD ,0. 5 g after HDin mild infection ,and 2 g before HD and 1 gafter HD in serious infection.