应用艾司洛尔和曲马多预防全麻拔管时的应激反应

The Preventive Stress Response under General Extubation Anesthe- sia with Esmolol And Tramado

目的观察将艾司洛尔和曲马多合用于气管拔管前对拔管期间的心血管反应的影响。方法择期手术病人50例,随机分成A组(艾司洛尔+曲马多,n=25)和B组(对照组),两组皆采用气管插管全麻。比较两组病人拔管期间的心血管反应,同时观察病人的镇静情况。结果A组拔管时,HR、MAP明显低于拔管前水平。B组HR拔管后5、10分钟与拔管前及A组同期比较均增幅显著(P<0.01),MAP拔管即时及拔管后均有所上升,与拔管前及A组同期比较以拔管时升高显著(P<0.05)。结论艾司洛尔合用曲马多用于气管拔管可预防拔管的应激反应,且病人安静。

Objective To investigate the effects of Esmolol and Tramadol on the alleviation of the reaction of cardiovascular during extubation . Methods Fifty selective surgical patients were randomly divided into group A(Esmolol+Tramadol;n=25) and group B (C ontrol) under general anesthesia .The reaction of cardiovas- cular was evaluated during extubation and the sedation was obsetived. Results In group A, the MAP and HR during extubation obviously decreased, lower than the level before extubation. During the same period, in group B, the HR,5,10 minutes after extubation increased significantly,higher than the level of group A and before extubation.(P<0.01). The MAP increased both during extubation and after extubation.It also in- creased significantly, higher than the level of group A and before extubation (P<0.05). Conclusion Esmolol combined with tramadol can prevent the stress reaction during extubation and patients were quiet .