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白三烯含量的测定推断损伤时间实际应用的探讨 被引量：4

THE TRIAL APPLICATION OF LTB4 LEVEL DETERMINATION IN WOUND FOR TIMING OF INJURY
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摘要 本文利用高压液相色谱法，检测大鼠切创创缘10％福尔马林固定皮肤检材的白三烯B4（LTB4）含量，结果发现：大鼠生前切创检材中LTB4含量增加，在1小时内其含量与损伤时间呈线性关系；死后伤未检见LTB4。随着福尔马林固定时间的延长，含量明显下降，但1周内仍可测出。 The level of LTB4 in incised skin wound edge of rats was determined by HPLC. The specimenswere fixed with formaha in advance. It was found that the content of LTB4 in all antemortemwounds was markedly increased. There was a linear relationbo between the content of LTB4 and thetime of injuries within 1h. LTB4 was markedly decreased after Formalin fixation. It could be detectedwithin 1 week.
作者 贺立文 祝家镇
机构地区 中山医科大学法医病理学教研室
出处 《中国法医学杂志》 CSCD 1994年第4期193-195,共3页 Chinese Journal of Forensic Medicine
关键词 法医学鉴定 液压液相色谱 损伤时间 白三烯B4 HPLC Time of injury LTB4
分类号 R89 [医药卫生—法医学]
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  • 1Simmons PM.4</sub> during experimental inflammation&amp;sid=Biochemical Pharmacology&amp;aufirst=Simmons PM');&#xA; ">The release of leukotriene B<sub>4</sub> during experimental inflammation. Biochemical Pharmacology . 1983
  • 2Henke DC,et al.Analysis of leukotriene s, prostaglandins, and other oxygenated metabolites of arachidonic acid by high-performance liquid chromatography. Analytical Biochemistry . 1984
  • 3Clancy RM,et al.The extraction of leukotrienes from tissue liquid: The metabolism of these mediators during IgE-dependent hypersensitivity reactions in lung. Analytical Biochemistry . 1983
  • 4Lewis RA.The biologically active leukotrienes. The Journal of Clinical Investigation . 1984
  • 5Salmon JA.Prostaglandins and leukotrienes as inflammatory mediators. British Medical Bulletin . 1987
  • 6Samuellson B.Leukotrienes: mediators of immediate bypersensitivity reactions and inflammation. Science . 1983
  • 7Posenbach T.Generation of leukotrienes from normal epidermis and their demonstration in cutaneous disease. British J Derm . 1985

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同被引文献4

  • 1孙洪涛,祝家镇.损伤皮肤中白三烯B_4含量测定与损伤时间推断[J].中国法医学杂志,1992,7(1):4-6. 被引量：4
  • 2Lasarov I, Franzova S, Russeva T. Changes in the amount of prostaglandin F2 alpha in incision wounds of the skin with different time intervals after injury[J]. Z Rechtsmed ,1988, 99(4):273～280
  • 3Kondo T, Ohshima T. The dynamics of inflammatory cytokines in the healing process of mouse skin wound: a preliminary study for possible wound age determination[J]. Int J Legal Med,1996, 108(5):231～236
  • 4傅晨钟 祝家镇.机械性损伤受伤时间推断的法医学研究进展[J].中国法医学杂志,1988,3(1):57-57.

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二级引证文献4

中国法医学杂志
1994年 第4期

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