特比奈芬治疗88例儿童甲真菌病临床观察

Effect of terbinafine in treating onychomycosis in children: clinical observation of 88 cases

目的观察特比奈芬治疗儿童甲真菌病的疗效及安全性。方法应用特比奈芬治疗儿童指甲真菌病50例及趾甲真菌病38例,并作疗效、真菌清除率及安全性观察。结果特比奈芬治疗儿童指甲真菌病的痊愈率及总有效率分别为92.1%和97.37%;趾甲真菌病则分别为86.36%和93.94%。真菌清除率均达到96.59%。在本临床研究中未发现特比奈芬有严重的毒副反应。结论特比奈芬治疗儿童甲真菌病疗效显著、安全性高,是有效根治儿童甲真菌病的方法之一。

Objective To observe the therapeutic effect and safety of terbinafine in treating onychomycosis in chidren. Methods Terbinafine was used to treat 50 children with fingernail onychomycosis and 38 with toenail onychomycosis, and the efficacy, fungal clearance and safety of the drug were evaluated. Results The clinical cure rate and total effective rate were 92.1% and 97.37%, respectively, for fingernail onychomycosis, and 86.36% and 93.94% for toenail onychomycosis, with fungal clearance rate of 96.59%. No serious side-effects was observed in the children receiving terbinafine therapy. Conclusion Terbinafine is effective and safe for the treatment of onychomycosis in children.