锰的发育毒性

Developmental Toxicity of Manganese

机体过量的锰暴露会导致进行性、持久性和神经变性的损害,严重者出现帕金森氏病样症状。锰对体外培养的胚胎神经细胞分化有抑制作用;锰可通过动物胎盘屏障进入胎儿体内,透过血脑屏障沉积于脑,引起脑形态学、生物化学和微量元素分布异常,神经行为机能障碍;人群调查显示母亲职业性接触锰可能会对子女智力产生有害的影响。因此,深入探讨锰的发育毒性,对保护工人及其子女身心健康具有十分重要的意义。

Overexposure to manganese can lead to progressive, permanent, neurodegenerative damage, resulting in syndromes similar to idiopathic Parkinson's disease. Manganese is an inhibitor to the differentiation of embryonic neurocyte cultured in vitro. Manganese can enter embryo body through placental-barrier, then accumulate in the brain through blood-brain barrier which may induce morphological, biochemical and microelement distributing abnormities in brain and alterations of nervous behavioral function. The population investigation indicated that it may be harmful to the children's intellect if their mothers have occupational overexposures to manganese. Therefore, it has very important to probe the developmental toxicity of manganese further for protecting the health of workers and their children.