第三代头孢菌素使用与耐甲氧西林葡萄球菌检出率关系的研究

Study on the relation between the use of the third generation cephalosporins and the varilance of methicillin - resistant staphylococcus.

目的 了解医院内分离的耐甲氧西林葡萄球菌(MRS)耐药性增高是否与第三代头孢菌素的使用增加相关,为抗生素的规范使用提供依据。方法 回顾1997年～2001年间,每年10月份MRS的分离率及全院抗生素及第三代头孢菌素的使用情况,用相关系数表示两者的相关性。结果 1997年～2001年抗生素的总使用率下降,由1997年的79.6％降到2001年的69.0％,而第三代头孢菌素的使用率显著增加,由1997年的8.61％到2001年的18.66％;MRS的增加与抗生素的总使用率无关,而与第三代头孢菌素的使用呈正相关(r=0.9511,P<0.01)。结论 虽然抗生素的总使用率下降,但第三代头孢的使用增加,MRS的增加与第三代头孢菌素使用呈正相关。要降低MRS的分离率,应减少第三代头孢菌素的不合理使用。

Objective To investigate the relation between the use of the third generation cephalosporins and the variance of methicillin -resistant staphylococcus(MRS) ,in order to lend a criterion for the clinical use of antibiotics in hospitals. Methods To review the data of MRS isolated on October every year from 1997 to 2001,and the use of the third generation cephalosporions at the same time,the relativity of them was determined by using coefficient of correlation. Results The total use of antibiotics was dropped, from 79.6% in 1997 to 69.0% in 2001. Increasing of MRS had no corelation with the total use of antibiotics, but had a positive correlation with the use of the third generation cephalosporins(r = 0.9511 ,P < 0.01) . Conclusions Although the total use of antibiotics was dropped, but the use of the third generation cephalosporins at the same time was increased The increasing of MRS was positively coeerlated with fhe use of the third geneiation cephalospoeins. The incerasing of MRS has positive coeerlatde with the use of the thied generation cephaoospoein. To erduce the isolation rate of MRS, the irrational use the thied generation f cephalospoeina should be avoided.