穿心莲内酯糖苷衍生物的合成

Synthesis of AndRographolide Glycosides Derivatives

目的:合成穿心莲内酯糖苷衍生物。方法:对穿心莲内酯的羟基进行糖苷化,合成了穿心莲内酯-葡萄糖苷,穿心莲内酯-半乳糖苷,穿心莲内酯-甘露糖苷。结果与结论:目标化合物经IR、HNMR、MS得到结构确证,可能具有更强的抗艾滋病的潜力。

Objective: In order to synthesis andrographolide glycosides. Method: Three andrographolide monosaccharides such as andrographolide-3, 19-O-β-D-glucoside, andrographolide-3 , 19-O-β-D-galactoside and andrographolide-3 , 19-O-α-D-mannoside were designed and successfully prepared. Result and Conclusion: The target compounds are identified by spectral methods and possessing a more potential activity of anti-HIV.