氟西汀治疗伴有情绪障碍表现的肠易激综合征患者的近期疗效观察

Short-term Effect of Fluoxetment in Treatment of Irritable Bowel Syndrome (IBS) with Mood Disturbance

目的:探讨氟西汀治疗伴有情绪障碍表现的肠易激综合征(IBS)患者的近期疗效,观察此类患者腹部症状与精神症状的相互关系。方法:40例伴有情绪障碍表现的肠易激综合征患者口服氟西汀8周,治疗前后分别对患者进行汉密尔顿抑郁量表(HAMD)和胃肠道症状计分标准(GSRS)的评估,观察疗效以及2种评分之间的相互关系。结果:有2例患者因出现不良反应退出研究,其余38例患者用药后的精神抑郁症状与腹部症状均有明显改善,治疗前后的HAMD和CSRS之间均存在显著差异(P<0.05)。而且HAMD与GSRS之间存在相关性(相关系数=0.65),表明肠易激综合征患者的腹部症状与情绪障碍之间存在一定相关性。结论:氟西汀对改善伴有情绪障碍的肠易激综合征患者的腹部症状及抑郁症状均有效果,提示抗抑郁治疗对此类患者有效。

Objective: To investigate the short-term effect of fluoxetine in treatment of irritable bowel syndrome (IBS) with mood disturbance and observe the relationship between patients'abdominal symptoms and mood score. Method: 40 IBS patients with mood disturbance were entered this study. Their mood scores and symptom scores were evaluated respectively according to Hamilton depression scale (HAMD) and gastroenteric symptom rating scale (GSRS) before treatment and 8 weeks'after treatment of fluoxetine. The relationship between the symptom releasement and the mood scores was observed. Result: Both the scores of mood disturbance and abdominal symptoms of 38 patients were significantly improved after the short-term treatment of fluoxetine. The HAMD and GSRS scores were obviously decreased 8 weeks after freatment (P <0. 05) and there was certain relationship between the two rating scales ( RR = 0.65). Conclusion: Antidepression treatment is effective in improving both the abdominal symptoms and mood disturbance in IBS patients with mood disturbance.