摘要
目的研究潘妥拉唑钠注射液对消化性溃疡合并上消化道出血的疗效.方法上海地区6家医院133例经内镜证实的消化性溃疡合并上消化道出血患者随机分为两组,其中潘妥拉唑治疗组100例,奥美拉唑治疗组33例.分别予以潘妥拉唑及奥美拉唑80 mg静脉滴注每日1次,连续5 d.结果潘妥拉唑组96例(96%)患者于3 d内止血,疗效判断为显效;4例(4%)患者于4~5 d内止血,疗效判断为有效;无效0例,总有效率为100%.奥美拉唑组32例(96.97%)患者于3 d内止血,疗效判断为显效;1例(3.03%)患者于4~5 d内止血,疗效判断为有效;无效0例,总有效率为100%.两组在治疗上消化道出血显效率及有效率方面均差异无统计学意义(P>0.05).结论潘妥拉唑是治疗消化性溃疡合并上消化道出血的有效药物.
Objective To investigate the effect of intravenous pantoprazole for the management of peptic ulcer bleeding. Methods One hundred and thirty three patients with endoscopic proved pepetic ulcer bleeding in 6 hospitals of Shanghai were randomized divided into two groups. One hundred cases were classified into pantoprazole group and 33 cases into omeprazole group, and they were given intravenous pantoprazole or omeprazole 80 mg daily respectively for 5 days. Results In pantoprazole group, the peptic ulcer bleeding in 96 cases (96%) stopped in 3 days , 4 cases (4%) in 4 to 5 days , while in omeprazole group, the bleeding in 32 cases (96.97%) stopped in 3 days , 1 case (3.03%) in 4 to 5 days .The total effective rate for controlling peptic ulcer bleeding was both 100% in two groups, there were no significant differences between two groups ( P >0.05). Conclusion Intravenous pantoprazole is effective in the management of peptic ulcer bleeding.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2005年第4期233-235,共3页
Chinese Journal of Digestion