急性脑出血患者一氧化氮、内皮素的改变及中药复苏饮对其的影响

Effect of Fusuyin on plasma endothelin and nitric oxide in patients with acute intracetebral hemorrhage.

目的观察复苏饮对急性脑出血患者内皮素(ET)、一氧化氮(NO)的影响。方法急性脑出血患者62例随机分为2组,中药组32例,对照组30例,中药组在对照组常规治疗基础上,给予中药复苏饮治疗。治疗14日观察ET、NO的变化。结果脑出血患者ET、NO明显较对照组提高(P<0.01)。复苏饮治疗后较对照组ET明显下降(P<0.05)。结论复苏饮可以抑制脑出血后患者血ET释放,保护内皮功能,减轻神经功能损伤。

Objective To observe the effect of Fusuyin on plasma endothelin and nitric oxide in patients with acute intracetebral hemorrhage.Method 62 cases with acute intracerebral hemorrhage were divided into two groups randomly,30 in routine therapy,and 32 using Fusuyin addition to routine methods.The plasma endothelin (ET) and nitric oxide (NO) concentration were assayed in 62 cases before and after treatment,and in 20 healthy volunteers.The concentration of ET and NO was measured using radioimmunal assay and nitrate reductase method respectively.Result The patients’ET and NO concentration were significantly higher than those of normal groups.But after Fusuyin treatment,the concentration of ET and were reduced,and comparing with routine therapy group, the difference is significant (P<0.05).Conclusion Fusuyin could inhibit the release of ET to ameliorate the functional disorder of endothelium,and mitigate nervous damage.