绿原酸对肠黏膜微血管内皮细胞分泌NO和ET-1的影响

The Effects of the Chlorgenic Acid on the NO and ET-1's Secreting of the Intestinal Mucosa Microvascualr Endothelial Cells

目的:探讨绿原酸对治疗大肠杆菌内毒素性疾病的作用机制。方法:利用体外培养大鼠肠黏膜微血管内皮细胞,研究金银花主要成分绿原酸对正常肠黏膜微血管内皮细胞作用1、3、6、9h后的NO和ET-1分泌量的影响,以及对经大肠杆菌内毒素作用1h后肠黏膜微血管内皮细胞于3、6、9h后的NO和ET-1分泌量的影响。结果:绿原酸有效地抑制了肠黏膜微血管内皮细胞分泌的ET-1和NO的比值升高。结论:绿原酸对内毒素作用下的肠黏膜微血管内皮细胞的功能有保护作用。

Objective:To investigate the treatment mechanism of the chlorgenic acid on the colibacillosis caused by LPS.Methods:The effects of the chlorgenic acid(the main component of the honeysuckle) on the NO and ET-1's secreting of intestinal mucosa microvascular endothelial cells of rats cultured in vitro in the 1,3,6,9 hours,and on the secreting in the 3,6,9 hours one hour after LPS was added were observed.Results:The chlorgenic acid can restrain the ratio of the secreting of the NO and ET-1 of the intestinal mucosa endothelial cells. Conclusion:The chlorgenic acid can protect the function of the intestinal mucosa microvascular endothelial cells from the damage of the LPS.