摘要
This paper describes experience with the se- quencing of synthetic segment peptides of gp41 which are used in trimeric peptides as potential peptide-based vaccines and as inhibitors to mimic the fusion state of gp41 in HIV infection using ESI/CID-FT-ICR MS. All b and y″ series ions are found in the CID spectra and the mass difference between the calculated and observed results is very slight. FT-ICR MS again shows its power in peptide sequencing, successfully helping us obtain the sequence of an unknown peptide.
This paper describes experience with the sequencing of synthetic segmentpeptides of gp41 which, are used in trimeric peptides as potential peptide-based vaccines and asinhibitors to mimic the fusion state of gp41 in HIV infection using ESI/CID-FT-ICR MS. AH b and y'series ions are found in the CID spectra and the mass difference between the calculated and observedresults is very slight. FT-ICR MS again shows its power in peptide sequencing, successfully helpingus obtain the sequence of an unknown
基金
supported by the National Natural Science Foundation of China(Grant No.20075002)
