人工肝支持系统治疗重型肝炎的临床研究

Clinical observation on the artificial liver support system in the treatment of severe hepatitis.

目的探讨人工肝支持系统(ALSS)治疗重型肝炎的治疗时期和临床疗效。方法47例重型肝炎为治疗组,应用ALSS治疗;94例重型肝炎为对照组,仅用综合疗法治疗。结果经ALSS治疗后,治疗组肝功能明显改善,临床症状得到一定程度改善,总治愈好转率为59.57%,显著优于对照组的40.42%(P<0.05);而早、中期重型肝炎治愈好转率为100.00%,与对照组(51.66%)比较有非常显著差异(P<0.005),但晚期重型肝炎中,ALSS治愈好转率为20.83%,对照组为6.00%,两组无显著差异(P>0.1)。结论ALSS治疗重型肝炎疗效可靠,在早、中期重型肝炎进行ALSS治疗效果较好。

Objective To study the efficacy of artificial liver support system(ALSS) in the treatment of severe hepatitis patients. Methods The treated group of 47 patients suffering from severe hepatitis were terated with ALSS. The control group of 94 cases were only treated with conventional therapy. Results In treated group, liver functions of the patients improved after ALSS therapy. The total effective rates were 59.57% in treated group and 40.42% in contol group. Significant difference were observed between the two groups(P<0.05). In early stage and middle stage of severe hepatitis, effective rate in the treated group was 100%,and effective rate in the control group was 51.66%. The effective rate in the treated group was significantly higher than that of control group (P<0.005). But no significant difference in effective rate between the treated group(20.83%)and control group(6%) in late stage of severe hepatitis was observed(P>0.1). Conclusion Artificial liver support system is effective for treatment of severe hepatitis in early stage.