流行性脑脊髓膜炎53例临床及流行病学分析

Analysis on epidemiological and chinical in 53 patients with epidemic meningitis

目的总结合肥市2004年上半年流行性脑脊髓膜炎(下称流脑)疫情动态,流行趋势,为今后流脑防治工作积累经验。方法对53例流脑患者病原学、临床流行病学等进行回顾性分析。结果53例患者中15岁以下38例,占71.7%;在2～4月份发病46例,占86.8%。随机抽取20例患者脑脊液及血清送检查,结果培养阳性14例,占70%,均为脑膜炎双球菌C群菌株。结论2004年上半年合肥市局部流行的流脑,主要病原体为脑膜炎双球菌C群菌株,发病有明显的季节性,且15岁以下儿童易感。因此,今冬明春有必要对易感人群接种A+C群脑膜炎球菌多糖疫苗(简称多糖菌苗)进行预防。

Objective To explore the epidemiological characteristics of epidemic meningitis,In order to develop the strategives for epidemic meningitis control and ilimination in Hefei city.Methods The virology and clinical epidemiological of 53 pationts were analysised retrospectively.Results Cases mainly were children under 15 years old,Occounting for 71.7%,mostly occurred in February to April,occounting for 86.8%,20 cases were tested from the cerebrospinal fluid (CSF) and the serological in random sampling,The results showed that 14 cases were group C meningococcus,occounting for 70%.Conclusion The main viras of epidemic meningitis was group C meningococcus in Hefei from January to June 2004,It is most important that sensitive children will be immunized by group A+C meningococcal polysaccharide vaccine in next Winter and Spring.[