黄连素对灰绿曲霉、黑曲霉的抑菌活性研究

Study on effects of bacteriostasis of berbering on crayish green aspergillus and aspergillus niger

用浓度为0.5mg/ml、1.0mg/ml、2.0mg/ml、4.0mg/ml和8.0mg/ml的黄连素药液制成相应的药敏片,检测黄连素对灰绿曲霉、黑曲霉的抑菌活性,并与制霉菌素进行比较。结果黄连素和制霉菌素对灰绿曲霉、黑曲霉均有抑菌活性,且随着浓度的增加其活性明显加强;相同浓度的黄连素对黑曲霉的抑菌活性强于灰绿曲霉(P<0.01),相同活力单位的制霉菌素对灰绿曲霉的抑菌活性(9.0万u/ml组除外)强于黑曲霉(P<0.01);浓度为8.0mg/ml的黄连素对灰绿曲霉中敏,对黑曲霉高敏(P<0.01)。

Effects of bacteriostasis of berbering on crayish green aspergillus and aspergillus niger was observed in the paper. The mdicine tablets, which were made from liquid berbering at different concentrations of 0.5mg/ml, 1.0 mg/ml, 2.0 mg/ml,4.0 mg/ml, and 8.0 mg/ml respectively, were taken in order to observe effects of bacteriostasis of berbering on crayish green aspergillus and aspergillus niger, and to compare its function with that of nystatin. The results were showed as follows: Both berbering and nystatin had effects of bacteriostasis on crayish green aspergillus and aspergillus niger, and action increased obviously according to the raise of concentration. Furthermore, at the same concentration, effects of bacteriostasis of berbering to aspergillus niger was significantly higher than to crayish green aspergillus (P<0.01). At the same vitality units, effects of bacteriostasis of nystatin to crayish green aspergillus (without the group of 9.0 ten thousand u/ml) was significantly higher than to aspergillus niger (P<0.01). At the concentration of 8.0 mg/ml, berbering had action of middling sensitivity on crayish green aspergillus, while had action of altitudinal sensitivity on aspergillus niger.