PTEN表达能否作为评估子宫内膜样腺癌术前高危因素指标的探讨

Possibility of PTEN Expression on Predicting Pathologic Risk Factors of Endometrioid Adenocarcinoma before Operation

背景与目的:子宫内膜癌术前高危因素的评估对于指导治疗及预后判断有着重要的意义。已有研究显示抑癌基因PTEN(第10染色体同源丢失性磷酸酶鄄张力蛋白基因)是子宫内膜癌中突变率最高的基因,也被称为子宫内膜的看家基因。本研究的目的就是探讨PTEN表达能否作为评估子宫内膜样腺癌术前高危因素的指标。方法:回顾性分析107例子宫内膜样腺癌病例的临床病理参数,用免疫组织化学方法检测子宫内膜样腺癌组织标本中PTEN蛋白的表达,分析PTEN表达情况与主要术前高危因素如细胞分化程度、子宫肌层浸润深度、淋巴转移的关系。结果:在107例子宫内膜样腺癌中PTEN表达缺失60例,占56.1%。χ2检验显示子宫内膜样腺癌中PTEN蛋白的表达与主要术前高危因素如细胞分化程度(P=0.695)、子宫肌层浸润深度(P=0.921)、淋巴转移(P=0.682)等,以及其他预后相关因素如手术分期(P=0.750)、雌孕激素受体表达(P=0.281;P=0.260)等均无显著性相关。结论:本研究结果未显示PTEN表达可作为子宫内膜样腺癌术前高危因素的指标。

BACKGROUND & OBJECTIVE: Fully estimating pathologic risk factors is important for selecting operation and predicting prognosis for endometrioid adenocarcinoma. Phosphatase and tension homology deleted on chromosome ten (PTEN), taken as the housekeeping gene of endometrium, has the highest mutation rate in endometrioid adenocarcinoma. This study was to investigate the effect of PTEN on predicting pathologic risk factors of endometrioid adenocarcinoma before operation. METHODS: Clinicopathologic data of 107 patients with endometrioid adenocarcinoma were retrospectively analyzed. The expression of PTEN was detected by SP immunohistochemistry. Correlations of PTEN to high risk factors, such as differentiation, myometrium invasion, and lymphatic metastasis, were analyzed. RESULTS: Deletion rate of PTEN was 56.1% in the 107 endometrioid adenocarcinoma patients. PTEN expression had no correlations to histological differentiation (P=0.695), myometrium invasion (P=0.921), lymphatic metastasis (P=0.682), surgical stage (P=0.750), estrogen receptor (P=0.281), and progestin receptor (P=0.260). CONCLUSION: Detection of PTEN can't predict the high risk factors of endometrioid adenocarcinoma before operation.