摘要
本实验采取琼脂平板稀释法测定了泰宁等7种抗菌药物对5种2l5株临床常见致病菌的最低抑菌浓度(MIC),并统计了敏感率,结果表明7种抗菌药物对大多数受试菌均显示了较高的抗菌活性,其中泰宁的抗菌活性最强。金黄色葡萄球菌、变形杆菌、大肠埃希氏菌、肺炎克雷白氏菌对泰宁的敏感率达97.6~100%;17.02%的绿脓假单胞菌耐药,4.26—12.77%绿脓假单胞菌和1株肺炎克雷白氏菌对泰宁和其他抗菌药物呈现部分交叉耐药性,而CPFX与其他抗菌药物对不同受试菌呈现2.38~19.05%的交叉耐药率,该结果提示对其他β-内酰胺类抗菌药物耐药的致病菌引起的严重感染,可考虑选用泰宁,但CPFX的选用还应根据药敏试验决定。
The minimum
inhibitory concentration(MIC) of 7 antimicrobialagents against 215strains of 5 species of
clinical isolates were determined by using agar disk dilution method and thesusceptible rates
were analyzed. The results showed that all 7 antimicrobial agents exhibited highactivity
against most of isolates tested, Among them the IMP/CS had best activity; the
susceptiblepercentage of S. aureus, Proteus sp,E. coli,K. pneumonia to the IMP/CS were high
up to97.6 100%;only 17.02%strains of ps aeruginosa were resistant to IMP/CS;2-6 strains of
Psaeruginosa and l strains of K. pneumonia were crossresistant to IMP/CS and other
antimicrobialagents. The crossresistant percentage of the isolates tested to CPFX and other
antimicrobialagents were 2.38-19.05%. The results suggested that IMP/CS may be used in
treatment of seriousinfections caused by clinical isolates resistant to other B-lactam
antimicrobial agents; the CPFXshould be selected according to the susceptibility test.
出处
《军医进修学院学报》
CAS
1994年第2期115-119,共5页
Academic Journal of Pla Postgraduate Medical School
关键词
抗生素
细菌敏感试验
耐药性
微生物学
antibiotics
bacterial sensitivity tests
drug resistance
microbiology