充血性心力衰竭患者肾素-血管紧张素-醛固酮活性

The changes and significance of renin-angiotensin-aldosterone lactivity in patients with chronic heart failure

目的探讨充血性心力衰竭(CHF)患者肾素血管紧张素醛固酮系统(RAAS)的活性。方法采用放免法测定收缩压(SBP)<13.33kPa的CHF患者(A组,25例),SBP>13.33kPa的CHF患者(B组,28例)及健康人(对照组,25例)血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)及醛固酮(ALD)水平。结果A组及B组血浆PRA、AngⅡ和ALD均明显高于对照组(P<0.05或0.01);A组血清钠、SBP及脉压/SBP显著低于对照组(P<0.05或0.01),A组血浆PRA、AngⅡ和ALD高于B组(P<0.05或0.01);A组血清钠、SBP及脉压/SBP显著低于B组(P<0.05或0.01)。结论CHF患者体内RAAS活性增高,且SBP<13.33kPa者高于SBP>13.33kPa者。

Objective To explore the renin-angiotensin-aldosterone system (RAAS) activityof patients with congestive heart failure(CHF).Methods 60 patients were divided into two groups according to their systolic blood pressure(SBP):①patients with SBP<13.33kPa (A,n=25); ②patients with SBP>13.33kPa (B,n=28).Normal control gruop incuded 23 health people. Plasmal levels of renin, angiotensin and aldosterone activity(PRA,AngⅡ and ALD) were measured by radio-immunity assay(RIA). Results Plasma levels of PRA, AngⅡ and ALD in A and B groups were significantly higher than those in control group(P<0.05 or 0.01),especially in A group (compared with B group, P< 0.05 or 0.01).A group had lower serum sodium, SBP and pulse pressure/systolic pressure compared with B group(P<0.05 or 0.01). Conclusion RAAS activity is increased in the CHF patients, especially in the patients with SBP lower than 13.33kPa.