慢性肾小球疾病患者血浆中部分抗凝和纤溶指标变化的探讨

Study on the Variance Partial Indexes of Anticoagulation and Fibrinolysin in Patients with Chronic Glomerulopathy

目的研究慢性肾小球疾病患者血浆中部分抗凝和纤溶物质与其止凝血障碍的关系。方法在STAGO-STA全自动血凝仪上检测79例慢性肾小球疾病患者和60名正常对照的血浆蛋白C(PC)、蛋白S(PS)、抗凝血酶(AT-)、纤溶酶原(PLG)和抗纤溶酶(AP)活性。结果与正常对照比较肾病综合征患者PC、PLG活性升高,有显著性差异(P<0.01);PS和AT活性降低(P<0.01),有显著性差异;AP升高,与正常对照无显著性差异。慢性肾炎患者PC升高(P<0.05),PLG升高(P<0.01),与正常组比较有显著性差异;PS和AT降低(P>0.05)与正常组比较无显著性差异,AP无变化。结论慢性肾小球疾病患者存在不同程度的凝血亢进和纤溶亢进,测定抗凝和纤溶系统的一些项目可帮助了解疾病的进展及指导治疗。

Objective To study the relationship between partial anticoagulant and fibrinolytic matter in the plasma of the patients with chronic glomerulopathy and their blood clotting disorder.Methods By the STAGO-STA auto-coagelometer,the activities of protein C(PC),protein S(PS),antithrombin Ⅲ(AT-Ⅲ),plasminogen(PLG) and antiplasmin(AP) were tested in 79 patients with chronic glomerulopathy and 60 normal volunteers.Results Comparing patients of nephrotic syndrome with the normal volunteers,the activities of PC and PLG increased(P<0.01),and there were significant differences between them.But the activities of PS and AT-Ⅲ declined(P<0.01),and there were significant differences between them.Comparing patients of chronic nephritis with the normal volunteers,the activities of PC increased(P<0.05),and the activites of PLG increased (P<0.01),and there were significant differences between them.The activities of PS and AT-Ⅲ declined(P>0.05),and there were no significant differences between them.Conclusion The chronic glomerulonephritis patients have different degrees of hypercoagulation and hyperfibrinolysis.Determing the anticoagulation system and fibrinolytic system can help find out the development of disease and help cure the disease.